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These patients are thought to be experiencing some type of central allodynia, in which their nervous systems seem to process normally non-painful sensory stimuli as being painful.12 This subset of patients probably led the early rheumatologists down the research path to look beyond the peripheral joints and soft tissues for a cause of their widespread pain

Additionally, setting realistic expectations is an important part of treatment planning

Together these roles reveal glutamines central position in energy provision for intestinal cells, immune resilience during strenuous activity, and a target for emerging anticancer strategies